|Annual Physics Cricket Match: pictured (left-right) unknown, Margaret M'Ewen, Maurice Wilkins, |
Bill Seeds, Bruce Fraser, Mary Fraser,
Raymond Gosling (standing) and Geoffrey
Maurice Wilkins recalls in his autobiography being beckoned by Fraser to view his helical model of DNA:
The model illustrated well the general understanding of DNA in the lab: the structure was helical based on the work of Wilkins and Alex Stokes; the phosphates were on the outside as indicated by Rosalind Franklin; the stacked central core of bases, or "pile of pennies" as shown by the x-ray diffraction photographs first achieved by William Astbury. However, whilst the model showed many of the correct characteristics in retrospect, it also reflected certain errors current at the time. A three chain structure was based on the water content and density data for DNA.Whilst both Wilkins and Franklin could not envisage anything less than three with that information (and had both separately told Fraser that the model had to be three chained) the Fraser model contradicted the X-ray diffraction data by showing the three chains to be equally spaced. The hydrogen bonding between the bases was also incorrect and the structure did not fit with Chargaff's 1:1 base ratios. The end result of the model was one of collective frustration as it summed up how the King's group had become trapped in the belief of a three chain structure and with no guidance as to how to construct it.
The model was never published, Bruce and Mary Fraser left the lab shortly afterwards and moved to Australia in 1952. There was a final act of drama as Maurice Wilkins urgently cabled Fraser in 1953 asking him to write up his model asap for publication in Nature.
|Telegram received by Maurice Wilkins from Bruce Fraser regarding publication of note on DNA model ( annotation by Maurice Wilkins)|
To read more about Bruce Fraser and his DNA model there is an excellent interview with him on the Australian Academy of Science website: http://www.science.org.au/scientists/interviews/f/bf.html
An earlier and more comprehensive blog on Bruce Fraser and his model is also available on the Linus Pauling blog: http://paulingblog.wordpress.com/2009/04/16/the-fraser-structure-of-dna/